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TREatment With Beta-blockers After myOcardial Infarction withOut Reduced Ejection fracTion"

Sponsored by Fundación Centro Nacional de Investigaciones Cardiovasculares Carlos III

About this trial

Last updated a year ago

Study ID

REBOOT-CNIC

Status

Completed

Type

Interventional

Phase

Phase 4

Placebo

No

Accepting

18+ Years
All Sexes

Trial Timing

Ended a year ago

What is this trial about?

REBOOT clinical trial will study whether long-term maintenance beta-blockers therapy results in a clinical benefit after heart attack without reduced left ventricular function. Half of the participants will be randomized to receive long-term beta-blocker therapy and the other half to no beta-blocker therapy after hospital discharge. All patients will be followed up for up to 5 years to determine the occurrence of adverse events (all cause mortality, re-infarction, and heart failure admission).

What are the participation requirements?

Inclusion Criteria

* ≥18 years old

* Admitted for STEMI or NSTEMI and invasive management (i.e. coronary angiography during index hospitalization).

* LVEF>40% as evaluated by any imaging technique anytime during hospitalization.

* Signed informed consent

Exclusion Criteria

* Known allergy or intolerance to beta-blockers

* Absolute contraindication to beta-blocker therapy according to treating physician judge

* Prior history of HF, Killip class on admission or during hospitalization ≥ II

* Severe valvular heart disease (> 3+ for aortic or mitral insufficiency, aortic or mitral valve area ≤1.0 cm2).

* Any condition (appart from AMI) that requires beta-blocker prescription on discharge according to treating physician judge

* Any medical condition that, in the investigator´s judgment, would seriously limit life expectancy (less than one year),

* Patients participating in other clinical trials