Insufficient Oxygenation in Septic Patients

Sponsored by Sanquin-LUMC J.J van Rood Center for Clinical Transfusion Research

About this trial

Last updated 2 years ago

Study ID

NL64824.058.18

Status

Completed

Type

Observational

Placebo

Accepting

18+ Years

All Sexes

Trial Timing

Ended 3 years ago

What is this trial about?

This study will describe the change of mitochondrial oxygen tension (mitoPO2) compared to traditional parameters of oxygenation and oxygen balance in the first 24 hours of septic patients admitted to the intensive care unit of an academic hospital. The mitoPO2 will be measured on prespecified measurement moments in the ICU. With each measurement moment, arterial and central venous blood gasses will be taken too.

What are the participation requirements?

Inclusion Criteria

* Age of patient is at least 18 years

* Patients diagnosed with sepsis in the emergency department or hospital ward

* Patients are admitted to the ICU via the hospital ward or emergency department

* Informed consent is given either by the patient or if the patient is too ill to give informed consent, by his or her legal representative.

* Patients have an arterial catheter in situ, since blood samples will be taken for the study. Most patients admitted to the ICU have an arterial catheter in place since it is part of standard care.

Exclusion Criteria

* Patients younger than 18 years

* Patients with sepsis discharged after emergency department visit

* Patients admitted to a hospital ward other than the ICU after emergency department visit

* Patients who cannot give informed consent themselves and without a legal representative will be excluded since no informed consent can be obtained

* Patients known with porphyria and/or photodermatosis will be excluded, since the risk of phototoxicity

* Patients with hypersensitivity to the active substance or to the plaster material of ALA (5-aminolevulinic acid)

* Pregnant or breast feeding women since there is no adequate data form the use of ALA in pregnant or breast feeding women

* Insufficient comprehensibility of the Dutch language