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Sugammadex To IMprove Bowel Function

Sponsored by Oregon Health and Science University

About this trial

Last updated 3 years ago

Study ID

21895

Status

Recruiting

Type

Interventional

Phase

Phase 4

Placebo

No

Accepting

18-75 Years
18+ Years
All
All

Not accepting

Not accepting
Healthy Volunteers

Trial Timing

Ended 2 years ago

What is this trial about?

Colon and rectal surgery is associated with high cost, long length of stay, high postoperative surgical site infection rate, high incidence of postoperative nausea and vomiting, and a high rate of hospital readmission. Return of bowel function is of utmost importance in avoiding patient discomfort, morbidity, and mortality after colorectal surgery. All patient having colorectal surgery receive neuromuscular paralysis, which is reversed at the end of surgery with either glycopyrrolate and neostigmine, or sugammadex. Glycopyrrolate and neostigmine both affect bowel function. Sugammadex has no effect on bowel function. The purpose of this study is to determine if a strategy of neuromuscular reversal with sugammadex, instead of glycopyrrolate and neostigmine, may increase gastric emptying after surgery and lead to less postoperative complications.

What are the participation requirements?

Yes

Inclusion Criteria

- Age ≥ 18 years

- Having surgery in the South Operating Rooms at Oregon Health & Science University

- Surgery scheduled Monday through Friday

- Having colorectal surgery

- Planned general endotracheal anesthesia

No

Exclusion Criteria

- Prisoners

- Pregnant women

- An inability to consent for surgery or anesthesia

- Allergy to a study drug

- Medical contraindication to neuromuscular blockade

- Stage 4 kidney disease or worse (glomerular filtration rate < 30 ml/min)

- Significant liver dysfunction (Aspartate transaminase or Alanine transaminase > twice the OHSU normal)

- Taking Toremifene

Locations

Location

Status

Recruiting