ProteIn Nutrition in Crohn's Disease

About this trial

Last updated 4 years ago

Study ID

297431

Status

Unknown

Type

Interventional

Phase

N/A

Placebo

Accepting

12 to 17 Years

All Sexes

Trial Timing

Ended 3 years ago

What is this trial about?

Muscles are essential for good quality of life. The investigators have shown that when children with Crohn's disease eat protein, only very little of it enters the muscles, leading to poor muscle growth and fatigue. The investigators want to find the reasons for this. The investigators will recruit 20 Crohn's disease patients and a matched group of healthy kids. The investigators will measure: * Daily food intake and muscle strength. * Protein absorption by giving our participants a milk protein test drink and take regular blood samples after. * Muscle mass with MRI. This study will help understand how protein is handled in these patients.

What are the participation requirements?

Inclusion Criteria

1. Age 12-17 years

2. BMI <30 kg/m2 (all)

3. **Documented diagnosis of CD previously confirmed by endoscopy and histology at least 6 months prior to enrolment (CD group only)

4. **Stable CD defined as no change in medication in the last 3 months (including corticosteroids) and no CD-related surgical intervention in the last 6 months (CD group only)

5. Able to participate fully in all aspects of the clinical trial (all)

6. Written informed consent obtained and documented (all) **n/a to HV's

Exclusion Criteria

1. A current diagnosis of UC, indeterminate colitis or microscopic colitis

2. A diagnosis of short-bowel syndrome

3. Serious underlying disease other than **CD that, in the opinion of the investigator, may interfere with the subject's ability to participate fully in the study

4. Contraindications for MRI scanning e.g. pacemaker

5. Dairy intolerance/milk protein allergy

6. Non-English speakers **n/a to HV's