About this trial
Last updated 3 years ago
Study ID
Nafesa Mostafa
Status
Completed
Type
Interventional
Phase
Phase 1
Placebo
No
Accepting
18 to 30 Years
All
Not accepting
Healthy Volunteers
Trial Timing
Ended 4 years ago
What is this trial about?
Dental caries is a biofilm-mediated, sugar-driven, multifactorial, dynamic disease that
results in the phasic demineralization and remineralization of dental hard tissues.
These tissues have poor regeneration capability because of the lack of both regenerative
cells and vascularization.
In the complex caries progression process involving dietary sugars, bacterial metabolism and
demineralization, the collagenous organic matrix becomes exposed and destroyed by resident
and bacterial proteases, allowing the lesion to expand
What are the participation requirements?
Inclusion Criteria
- Patients included in the study will be required to present at least one permanent molar with an active deep carious lesion without pulpal involvement.
- Age of patient: 18 -30 years
- Carious lesions will be standardized by means of clinical and radiographic examinations performed before the procedures
Exclusion Criteria
- Teeth with deep dentinal lesions with pulpal involvement, abscess, pain or swelling
- Developmental disorders and adjacent soft tissue lesions
- Patients with systemic illness will be excluded