About this trial
Last updated 2 years ago
Study ID
Status
Type
Phase
Placebo
Accepting
Trial Timing
Ended a year ago
What is this trial about?
What are the participation requirements?
Inclusion Criteria
- (HI Cohorts Only): Stable HI that meets criteria for Class A or B of the Child-Pugh classification;
- (all Cohorts): BMI of 17.5 to 38.0 kg/m2
Exclusion Criteria
- Any condition possibly affecting drug absorption Additional Exclusion Criteria for HI Cohorts Only
- Limited predicted life expectancy
- Hepatic dysfunction secondary to acute ongoing hepatocellular process.
- Signs of clinically active Grade 2, 3 or 4 hepatic encephalopathy.
- Severe ascites and/or pleural effusion
- History of kidney, liver, or heart transplantation.
- Persistent severe, uncontrolled hypertension.