Study of the Glycemic Effects of Nebivolol Compared With Metoprolol and HCTZ in Diabetic Hypertensive Patients

- Male or female, 18-85 years of age

- Blood pressure in the range of 130 to 179/80 to 109 mmHg

- Currently using either an ACE inhibitor or an ARB alone or (an ACE inhibitor or an ARB and up to two other drugs for treatment of high blood pressure). (Patients may be on both an ACE inhibitor and ARB, but would need to be taken off one.)

- Stable medication regimen for high blood pressure for at least one month prior to screening

- Stable type 2 diabetes mellitus for at least 3 months prior to screening that is controlled by any or all of the following: diet and antidiabetic medications that may include fixed-dose insulin

- HgbA1c 6.5 to 8.5% (This is measured at the screening visit)

- Use of any beta blocker within one month prior to screening

- Use of clonidine within 3 months prior to screening

- Diagnosis of hyperthyroidism as evidenced by abnormal lab markers

- Any disorder requiring the intermittent or chronic use of systemic corticosteroids

- Diagnosis of hyperthyroidism as determined by lab markers done at screening

- Active liver disease as determined by lab markers

- Kidney impairment; estimated GFR < 60 mL/min/1.73 m2

- History of heart attack, clinically significant arrhythmia, unstable angina, coronary angioplasty/bypass surgery, stroke, or TIA in 3 months prior to screening

- Chronic heart failure

- Drug or alcohol abuse within 2 years prior to screening

- History of sensitivity to any beta blocker, HCTZ, sulfa drug, or calcium channel blocker

- Participation in another research study within 30 days prior to screening